Research & Development

Redx Pharma is focused on the discovery and development of proprietary, small molecule therapeutics to address areas of high unmet medical need, in cancer, immunology and infection. By improving the characteristics of existing drug classes, we aim to create differentiated, novel drugs.

Redx has an established portfolio of proprietary drug programs that it is developing alone and in partnership with leading pharmaceutical companies and healthcare bodies. Two of our high value programs are advancing into Phase I clinical development for for gastric, biliary and pancreatic cancers, and leukaemia.

It is our aim that our discoveries will provide a pipeline of potential assets to complement and combine with the drug portfolios of larger and emerging pharmaceutical companies.

Redx Pharma is currently accelerating the development of two key assets in oncology and immunology:

  • RXC004 – best-in-class Porcupine inhibitor

Porcupine is a key enzyme in the oncogenic Wnt signalling pathway. This pathway is implicated in a range of hard-to-treat cancers with poor prognosis such as pancreatic, biliary and gastric cancers. Our Porcupine inhibitor, RXC004, is a potent inhibitor of this enzyme and pathway, leading to strong tumour growth inhibitory effects in a variety of cancer models.

We have recently shown that RXC004, when administered together with an immune checkpoint inhibitor (anti-PD-1) has a synergistic immune system modifying effect.

  • RXC005 – best-in-class reversible BTK inhibitor

BTK is a key biological enzyme target which has been validated by the approval of the drug ibrutinib (Imbruvica™) in the treatment of a range of blood cancers, such as chronic lymphocytic leukaemia. Our reversible BTK inhibitor, RXC005, has shown potent inhibitory activity towards wild-type (normal) BTK as well as mutant BTK (C481S), the latter of which is refractory to ibrutinib inhibition.

Our Pipeline page provides more information on the programs currently in development.